Christopher G Kevil Selected Research

Ischemia

12/2023	Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation.
1/2020	Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO.
1/2014	Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner.
10/2013	Control of angiogenesis dictated by picomolar superoxide levels.
9/2013	Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis.
12/2012	Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension.
10/2012	Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.
7/2012	Nitrite anion stimulates ischemic arteriogenesis involving NO metabolism.
5/2012	Nitrite and nitric oxide metabolism in peripheral artery disease.
1/2011	Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.

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Christopher G Kevil Research Topics

Disease

16	Neoplasms (Cancer) 07/2023 - 03/2004
15	Ischemia 12/2023 - 05/2005
13	Inflammation (Inflammations) 07/2023 - 02/2006
11	Cardiovascular Diseases (Cardiovascular Disease) 02/2024 - 10/2013
11	Hypoxia (Hypoxemia) 12/2023 - 05/2005
11	Colitis 01/2020 - 02/2006
7	Vascular Remodeling 01/2020 - 07/2012
6	Reperfusion Injury 01/2023 - 05/2008
5	Mitochondrial Diseases (Mitochondrial Disease) 02/2024 - 01/2019
5	Atherosclerosis 01/2023 - 05/2012
5	Cardiomyopathies (Cardiomyopathy) 01/2023 - 01/2019
5	Fibrosis (Cirrhosis) 12/2022 - 01/2018
5	Peripheral Arterial Disease 02/2014 - 05/2008
4	Cardiomegaly (Heart Hypertrophy) 07/2023 - 11/2020
4	Heart Failure 01/2023 - 09/2013
4	Carcinogenesis 10/2021 - 02/2011
3	Myocardial Infarction 01/2023 - 05/2005
3	COVID-19 01/2023 - 01/2021
3	Hypertension (High Blood Pressure) 01/2021 - 12/2012
3	Pathologic Processes 10/2020 - 08/2011
3	Pathologic Neovascularization 01/2020 - 02/2009
3	Hyperglycemia 01/2018 - 01/2011
3	Diabetes Mellitus 02/2014 - 01/2012
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2013 - 12/2004
3	Infarction (Infarctions) 08/2009 - 12/2004
2	Hyperemia 01/2024 - 01/2015
2	Muscular Atrophy (Muscle Atrophy) 03/2023 - 01/2022
2	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2021
2	Dementia (Dementias) 01/2023 - 01/2021
2	Cognitive Dysfunction 01/2023 - 01/2021
2	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2022 - 01/2019
2	Neoplasm Metastasis (Metastasis) 09/2021 - 11/2018
2	Thyroid Neoplasms (Thyroid Cancer) 09/2021 - 11/2018
2	Genomic Instability 01/2021 - 01/2019
2	Brain Injuries (Brain Injury) 01/2021 - 12/2004
2	Hyperhomocysteinemia 10/2020 - 01/2018
2	Vascular Diseases (Vascular Disease) 10/2020 - 10/2013
2	Arteriovenous Fistula 12/2019 - 10/2019
2	Atherosclerotic Plaque (Atheroma) 01/2019 - 08/2017
2	Necrosis 01/2014 - 05/2005
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2011 - 04/2006
2	Chronic Limb-Threatening Ischemia 05/2008 - 09/2007
1	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2024
1	Atrophy 01/2023
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2023

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 02/2024 - 02/2009
18	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2024 - 09/2007
16	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 09/2021 - 10/2012
13	NitritesIBA 01/2018 - 05/2005
11	EnzymesIBA 03/2023 - 10/2016
10	Sulfides (Thioethers)IBA 01/2023 - 08/2017
7	Sodium NitriteIBA 02/2014 - 05/2005
6	Dextrans (Dextran)FDA Link 01/2020 - 04/2006
6	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2020 - 04/2006
5	AntioxidantsIBA 03/2023 - 01/2011
5	LipidsIBA 03/2023 - 02/2009
5	LyasesIBA 01/2023 - 01/2015
5	CystathionineIBA 01/2023 - 01/2015
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 04/2006
4	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2023 - 01/2019
4	Glutathione (Reduced Glutathione)IBA 01/2022 - 01/2007
4	Peptides (Polypeptides)IBA 01/2018 - 02/2009
4	AnionsIBA 01/2014 - 02/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2024 - 10/2013
3	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2024 - 10/2019
3	Cystathionine gamma-Lyase (Cysteine Desulfhydrase)IBA 12/2023 - 01/2018
3	polysulfideIBA 12/2023 - 01/2020
3	IronIBA 07/2023 - 05/2005
3	CollagenIBA 01/2022 - 08/2017
3	Oxygen (Dioxygen)IBA 01/2021 - 09/2012
3	GasotransmittersIBA 01/2021 - 03/2015
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 02/2015 - 06/2007
3	ProdrugsIBA 01/2014 - 02/2011
3	Protein Isoforms (Isoforms)IBA 09/2013 - 07/2011
3	Dipyridamole (Persantine)FDA LinkGeneric 01/2011 - 03/2010
3	Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA 02/2006 - 08/2004
2	NeurograninIBA 02/2024 - 01/2022
2	Indicators and Reagents (Reagents)IBA 01/2023 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 09/2022 - 01/2021
2	Apolipoproteins E (ApoE)IBA 01/2022 - 08/2017
2	Superoxides (Superoxide)IBA 01/2022 - 10/2013
2	Dynamins (Dynamin)IBA 12/2020 - 01/2020
2	Caveolin 1IBA 01/2020 - 02/2009
2	SulfurIBA 01/2018 - 10/2016
2	CytokinesIBA 01/2015 - 02/2006
2	NitratesIBA 01/2014 - 12/2009
2	ChemokinesIBA 08/2012 - 01/2008
2	S-NitrosothiolsIBA 10/2010 - 05/2005
2	Recombinases (Recombinase)IBA 06/2007 - 02/2006
2	IntegrinsIBA 04/2006 - 12/2004
1	Nerve Growth Factor (NGF)IBA 02/2024
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 02/2024
1	Adenylate KinaseIBA 12/2023
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 07/2023
1	Pulmonary Surfactant-Associated ProteinsIBA 01/2023
1	VaccinesIBA 01/2023

Therapy/Procedure

16	Therapeutics 11/2021 - 03/2004
4	Ligation 01/2020 - 07/2012
3	Drug Therapy (Chemotherapy) 09/2021 - 11/2018
2	Transplantation 11/2021 - 05/2005